[1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II), DCM adduct
CAS 95464-05-4
Pd(dppf)Cl₂·DCM is the workhorse pre-catalyst for Miyaura borylation and for Suzuki couplings involving alkyl or heteroaryl partners, where its bite-angle-optimized ferrocenyl ligand suppresses β-hydride elimination and protodeboronation.
Typical specification
| Molecular formula | C₃₄H₂₈Cl₂FeP₂Pd · CH₂Cl₂ |
|---|---|
| Molecular weight | 816.64 |
| Assay | ≥ 98% |
| Palladium content | 12.8 – 13.2% |
| Appearance | Dark red-brown crystalline powder |
| Form | 1:1 dichloromethane adduct |
| Iron content | 6.7 – 7.1% |
| Solubility | Soluble in DCM, DMF, DMSO; sparingly soluble in alcohols |
| HS code (export) | 2843900099 |
Lot-specific COA issued with every shipment. SDS and ICP elemental impurity data available on request.
Where Pd(dppf)Cl₂·DCM is used
Miyaura borylation
The catalyst of record for converting aryl halides to pinacol boronates with bis(pinacolato)diboron — a near-universal step in modern API routes for installing the boron handle ahead of a Suzuki coupling.
Suzuki coupling of difficult partners
Preferred for sp³ alkylboron couplings, heteroaryl chlorides prone to catalyst poisoning, and substrates where β-hydride elimination degrades yields with monodentate phosphine systems.
Kumada and carbonylative couplings
Its wide-bite-angle chelate performs well in Kumada couplings of Grignard reagents and in carbonylation chemistry, giving reproducible selectivity at loadings of 0.5–3 mol%.
Storage and shipping
Storage. Store sealed, cool and dry under inert gas. Considerably more air-stable than Pd(0) complexes; avoid prolonged exposure to humid air.
Shipping. Ships by commercial courier in sealed glass under nitrogen with SDS; not temperature-critical in transit.
Packaging. 5 g · 25 g · 100 g · 500 g · 1 kg
Synonyms
- Pd(dppf)Cl2 dichloromethane complex
- PdCl2(dppf)·CH2Cl2
- 1,1'-Bis(diphenylphosphino)ferrocene palladium dichloride
- Dichloro(dppf)palladium(II) DCM adduct
Frequently asked questions
DCM adduct or adduct-free — which should I order?
The DCM adduct (this listing, CAS 95464-05-4) is the common commercial form with better crystallinity and handling. If your process bans dichloromethane residues, we also supply the adduct-free complex (CAS 72287-26-4) — state this in your inquiry.
How is the quote built?
Contained palladium (~13%) is priced on the day's Pd fixing; ligand and conversion are a stated fabrication charge. The two legs are itemized so procurement can benchmark either independently.
Is this complex air-stable enough for open handling?
Brief weighing in air is fine; it is far more forgiving than Pd(0) complexes. For storage, keep it sealed under inert gas and dry — hydrolysis over months slowly erodes activity.
What documentation is included?
COA with assay, Pd and Fe content, and appearance; SDS in English; ICP impurity panel available for GMP-adjacent use.