Bis(tricyclohexylphosphine)palladium(II) acetate
CAS 59840-38-9
Pd(OAc)₂(PCy₃)₂ is a pre-formed, bench-stable precatalyst that pairs the electron-rich, bulky tricyclohexylphosphine ligand with a palladium acetate core — delivering PCy₃ catalysis without the need to weigh and store air-sensitive free phosphine.
Typical specification
| Molecular formula | Pd(CH₃COO)₂[P(C₆H₁₁)₃]₂ |
|---|---|
| Molecular weight | 785.37 |
| Assay | ≥ 98% |
| Palladium content | ≥ 13.5% |
| Appearance | Off-white to pale-yellow crystalline powder |
| Pd : phosphine ratio | 1 : 2 (pre-formed) |
| Solubility | Soluble in DCM, chloroform, toluene, THF |
| Packaging atmosphere | Nitrogen |
| HS code (export) | 2843900099 |
Lot-specific COA issued with every shipment. SDS and ICP elemental impurity data available on request.
Where Pd(OAc)₂(PCy₃)₂ is used
Coupling of aryl chlorides and hindered substrates
The strongly σ-donating PCy₃ ligand promotes oxidative addition into C–Cl bonds, enabling Suzuki–Miyaura and Heck couplings of inexpensive aryl chlorides and sterically demanding partners at modest loading — chemistry where triphenylphosphine systems stall.
Carbonylation and C–N bond formation
A reliable catalyst for alkoxy- and aminocarbonylation and for Buchwald–Hartwig amination of hindered amines, where the wide cone angle of PCy₃ accelerates reductive elimination.
Handling advantage over in-situ ligation
Free tricyclohexylphosphine is air-sensitive and awkward to charge accurately at scale. The pre-formed complex fixes the Pd:ligand ratio at 1:2, removing a weighing step and a common source of batch-to-batch variability in process chemistry.
Storage and shipping
Storage. Store sealed, cool and dry under inert gas. Far more convenient to handle than free tricyclohexylphosphine, which oxidizes readily in air.
Shipping. Ships in sealed glass under nitrogen by commercial courier with SDS; not classified as dangerous goods in standard pack sizes.
Packaging. 1 g · 5 g · 25 g · 100 g · Bulk under inert gas
Synonyms
- Pd(OAc)2(PCy3)2
- Palladium acetate tricyclohexylphosphine complex
- Bis(tricyclohexylphosphine)palladium diacetate
- Diacetatobis(tricyclohexylphosphine)palladium(II)
- PCy3 palladium precatalyst
Frequently asked questions
Why buy the pre-formed complex instead of Pd(OAc)₂ plus PCy₃?
Free tricyclohexylphosphine oxidizes in air and must be handled under inert conditions, and any error in the Pd:ligand ratio shows up as irreproducible activity. The pre-formed complex is bench-stable, fixes the ratio at 1:2, and removes a weighing operation from your process.
How is pricing structured?
Contained palladium (~13.6%) is quoted against the day's Pd fixing; the phosphine ligand and complexation are a stated fabrication charge. At this Pd percentage the ligand chemistry, not the metal, dominates cost — so pricing is relatively stable against palladium market swings.
What documentation ships with the product?
A lot-specific certificate of analysis with assay, Pd content and appearance, plus an English SDS. ICP elemental impurity data is available for pharmaceutical customers.
Do you take back spent catalyst?
Yes — spent catalyst and Pd-bearing reaction residues are assayed on receipt and the recovered palladium credited against your next order.