Tetrakis(triphenylphosphine)palladium(0)
CAS 14221-01-3
Pd(PPh₃)₄ is the most widely specified Pd(0) catalyst in the literature — the default choice for Suzuki, Stille, Sonogashira and Negishi couplings of aryl bromides and iodides, and a benchmark against which newer ligand systems are compared.
Typical specification
| Molecular formula | Pd[P(C₆H₅)₃]₄ |
|---|---|
| Molecular weight | 1155.56 |
| Assay | ≥ 99% |
| Palladium content | 9.0 – 9.5% |
| Appearance | Bright-yellow crystalline powder |
| Melting point | ~115 °C (dec.) |
| Quality indicator | Free-flowing yellow crystals; green/brown tint indicates oxidation |
| Packaging atmosphere | Argon, amber glass |
| HS code (export) | 2843900099 |
Lot-specific COA issued with every shipment. SDS and ICP elemental impurity data available on request.
Where Pd(PPh₃)₄ is used
Suzuki–Miyaura and Stille coupling
The standard catalyst for couplings of aryl and vinyl bromides/iodides with boronic acids or stannanes at 1–5 mol% loading. Its ubiquity in published routes makes it the lowest-friction choice when reproducing literature procedures during route scouting.
Sonogashira and Negishi reactions
Used with or without copper co-catalyst for alkynylation, and with organozinc reagents for sp²–sp³ couplings — common steps in kinase-inhibitor and agrochemical intermediate synthesis.
Allylic substitution and deprotection
Catalyzes Tsuji–Trost allylation and the removal of Alloc/allyl protecting groups under mild conditions, a standard operation in peptide and carbohydrate chemistry.
Storage and shipping
Storage. Store cold (2–8 °C) under inert gas, protected from light. Oxygen-sensitive: darkening toward green or brown indicates oxidation.
Shipping. Packed under argon in amber glass; cold-chain courier available for summer shipments on request.
Packaging. 5 g · 25 g · 100 g · 500 g · Bulk under argon
Synonyms
- Pd(PPh3)4
- Tetrakis palladium
- Palladium tetrakis(triphenylphosphine)
- Tetrakis(triphenylphosphane)palladium(0)
- TKP
Frequently asked questions
How should I judge lot quality on arrival?
Color is the fastest check: fresh material is uniformly bright yellow. Green or brown discoloration signals phosphine oxidation and lower active Pd(0) content. Every lot we ship is packed under argon with the production date on the COA.
How is pricing structured?
Palladium is only ~9% of the molecular weight, so the ligand and processing dominate cost at small scale; at kilogram scale the metal leg is quoted against the day's Pd fixing and can be fixed forward.
What is the shelf life?
Twelve months unopened under argon at 2–8 °C is typical. We ship recently manufactured lots and state the production date, rather than warehouse stock of unknown age.
Do you accept spent catalyst back?
Yes — spent Pd(PPh₃)₄ residues and reaction filter cakes are assayed and the palladium credited against your next order.