Tetrapropylammonium perruthenate (TPAP)
CAS 114615-82-6
TPAP is the Ley–Griffith oxidation catalyst — the mild, chemoselective reagent that converts primary alcohols to aldehydes with NMO co-oxidant at room temperature, a fixture of complex-molecule and API synthesis.
Typical specification
| Molecular formula | (C₃H₇)₄N·RuO₄ |
|---|---|
| Molecular weight | 351.43 |
| Assay | ≥ 97% |
| Ruthenium content | ≥ 28.8% |
| Appearance | Dark green crystals |
| Solubility | Soluble in DCM, MeCN |
| HS code (export) | 2843900099 |
Lot-specific COA issued with every shipment. SDS and ICP elemental impurity data available on request.
Where TPAP is used
Ley–Griffith alcohol oxidation
Catalytic TPAP with NMO oxidizes primary alcohols cleanly to aldehydes without over-oxidation — the go-to method when substrates carry acid- or base-sensitive functionality.
Late-stage oxidation in API routes
Its functional-group tolerance and catalytic loading (typically 5 mol%) make TPAP a standard tool in multi-step pharmaceutical syntheses, with ruthenium recovered from spent reaction residues.
Storage and shipping
Storage. Store cold (2–8 °C), sealed and dry, away from combustibles; oxidizing salt.
Shipping. Oxidizer handling notes supplied; shipped in sealed glass with SDS.
Packaging. 1 g · 5 g · 25 g
Synonyms
- Ley–Griffith catalyst
- Tetra-n-propylammonium perruthenate
- TPAP oxidant
- Pr4N RuO4
Frequently asked questions
How should TPAP be stored for shelf life?
Cold, dry and sealed — the salt slowly loses activity with moisture exposure. We ship recently produced lots with production date on the COA rather than aged warehouse stock.
How is pricing structured?
Quotes reference the day's ruthenium price on assayed contained metal plus a stated conversion charge; ruthenium's low price among PGMs makes it the economical choice wherever it can do the job.
Do you take back spent material?
Yes — spent catalyst, coating residues and off-spec lots are assayed on receipt and the recovered ruthenium credited against your next order.